NFL Leaders |
Sacks
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | T. Watt | Pit | 15 | 53 | 15.0 | 112.5 | 1 | 2 | 7 |
| 2t | A. Donald | LAR | 16 | 45 | 13.5 | 86.0 | 0 | 4 | 1 |
| 2t | T. Hendrickson | NO | 15 | 25 | 13.5 | 71.0 | 0 | 1 | 1 |
| 4t | H. Reddick | Ari | 16 | 62 | 12.5 | 83.5 | 0 | 6 | 4 |
| 4t | Z. Smith | GB | 16 | 52 | 12.5 | 81.5 | 0 | 4 | 2 |
| 6 | M. Garrett | Cle | 14 | 48 | 12.0 | 98.0 | 0 | 4 | 2 |
| 7 | L. Williams | NYG | 16 | 57 | 11.5 | 101.5 | 0 | 0 | 1 |
| 8 | S. Tuitt | Pit | 15 | 45 | 11.0 | 63.5 | 0 | 2 | 3 |
| 9 | L. Floyd | LAR | 16 | 55 | 10.5 | 71.0 | 0 | 1 | 1 |
| 10 | R. Okwara | Det | 16 | 44 | 10.0 | 79.0 | 0 | 3 | 1 |
| 11t | J. Adams | Sea | 12 | 83 | 9.5 | 39.5 | 0 | 1 | 3 |
| 11t | D. Buckner | Ind | 15 | 58 | 9.5 | 58.0 | 0 | 2 | 3 |
| 11t | J. Pierre-Paul | TB | 16 | 55 | 9.5 | 62.0 | 2 | 4 | 6 |
| 14t | B. Burns | Car | 15 | 58 | 9.0 | 78.0 | 0 | 3 | 4 |
| 14t | K. Mack | Chi | 16 | 50 | 9.0 | 64.0 | 1 | 3 | 3 |
| 14t | E. Ogbah | Mia | 16 | 43 | 9.0 | 95.5 | 0 | 3 | 5 |
| 14t | M. Sweat | Was | 16 | 45 | 9.0 | 83.0 | 1 | 2 | 6 |
| 14t | O. Vernon | Cle | 14 | 36 | 9.0 | 45.0 | 0 | 1 | 3 |
| 14t | D. White | TB | 15 | 140 | 9.0 | 70.0 | 0 | 1 | 4 |
| 20 | K. Hyder | SF | 16 | 49 | 8.5 | 46.5 | 0 | 0 | 0 |
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